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pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can minimize panobinostat amounts by ~70% and lead to procedure failure.pentobarbital will minimize the extent or result of darifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Cautio